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Nipponese researcher have created a potentially endless line of mice clone from other cloned mouse . They used the same technique that createdDolly the sheepto get 581 mouse from an original bestower computer mouse through 25 round of cloning , the scientist account in the March 7 egress of the journal Cell Stem Cell .
Mice can be cloned from other mice indefinitely, a new technique suggests.
" This technique could be very useful for the large - scale production of superior - quality animate being , for husbandry or preservation intention , " written report leader Teruhiko Wakayama of the RIKEN Center for Developmental Biology in Kobe , Japan , say in a command .
The investigator used acloning techniquecalled somatic cell nuclear transfer , in which a cell nucleus hold one someone ’s genetic information is inserted into an bollock cell whose nucleus has been removed . Dolly the Sheep became the first cloned mammal in 1996 using this technique . Many other brute have been cloned since , but the technique has had a low-down success rate and attempt to " reclone " animals have often run out .
Genetic abnormalities that can gather over straight generations of clones may explain these failures , Wakayama said . [ That ’s Odd ! The 10 Weirdest Animal Discoveries ]
In their discipline , Wakayama and colleague grew the cloned cells in a solvent containing trichostatin , a compound that interferes with enzyme that make changes to DNA . Using this technique , the cloning operation was five times more successful .
The team successfully clone the mice 25 serial times . In other language , they cloned one mouse , then cloned those clones , and so on . A total of 581 healthy mice were made , all of which were fertile and lived a normal life duo of about two eld . The efficiency of making the cloned cells neither worsened nor improved over the generation .
" This is a very important set of results , " geneticist George Church of Harvard Medical School recount LiveScience . It ’s " not just that it ’s 25 sequential clonings , it ’s that they found a path to improve things five - fold , " Church said . see out what did n’t work out was equally important , he contribute .
No abnormalities pile up in the mouse , even after take over cloning , the researchers found . " Our results show that repeated reiterative recloning is possible and propose that , with adequately efficient proficiency , it may be potential to reclone animals indefinitely , " the authors wrote in the subject area .
In 2008 , Wakayama ’s team created clon from the bodies of mouse that had been freeze for 16 years . Other researchers have successfullyrecloned kine , pigsand guy , but not beyond three generations . Scientists have also created stem cadre from cloned human embryos , but ethical and scientific roadblock to human cloning remain .
