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A new " digital pill " can distinguish doctors whether a affected role has taken his or her medicinal drug . The tablet , which wasapprovedby U.S. Food and Drug Administration on Nov. 13 , sends a signal to a wearable sensor when a patient has taken the medication , and that information is then sent to a doc ’s situation .
The whole system is call Abilify MyCite , and consists of the pill , the wearable detector and a smartphone app . The actual drug is Abilify ( generic name aripiprazole ) , a medication used to treatschizophreniaand bipolar disorder . The drug is sold by Otsuka Pharmaceutical , and the sensor in the pill was built by Proteus Digital Health .
Abilify MyCite comes with an adhesive sensor (seen in the lower left of this image) and a smartphone app.
But how does the system turn ? [ Bionic man : Top 10 Technologies ]
Though the idea may go like something out of a sci - fi movie , the technology is based on a principle first adumbrate more than 200 year ago , said Dr. George Savage , chief aesculapian ship’s officer and co - founding father of Proteus Digital Health .
In 1800 , Alessandro Volta invent a barrage fire lie in of two unlike metals ( zinc and copper color ) in a solution of sulphuric window pane and brine , Savage said . Batteriesare made in a similar way to this day .
Abilify MyCite comes with an adhesive sensor (seen in the lower left of this image) and a smartphone app.
Embedded in the pill is a sensing element that consist of a atomic number 14 chip with the logic circuit , along with two piece of metal : copperandmagnesium , Savage told Live Science . When the sensor is sink into a solution of piddle or any other liquidness that has diametric molecules ( such as the hydrochloric battery-acid in the abdomen , which dissolves the anovulant , leave the sensor behind ) , the equipment will generate a electric current . The current is very small , but it ’s enough to unravel the chip .
" Technically , it ’s a partial baron source , " Savage said . " The patient becomes the barrage fire . "
Once activated , the chip — only 1 mm on a side , and 0.3 millimetre thick — sends a very dewy-eyed signal , one that encodes only a single issue . That number identify the oral contraceptive pill and tells the wearable , adhesive detector — essentially an adhesive bandage , Savage said — that it has been ingested .
The pill ’s signaling is n’t a radio sign , though , Savage say . The poker chip ’s logic electric circuit makes a small modulate stream — a graph of the current stratum would look like a sine waving . Since the human body is conductive , thewearable sensorcan cull up the changes . The modulated current can encode unity and zeroes , similar to an FM sign , Savage said .
" It turn in a standardized way as an cardiogram , " or electrocardiogram , Savage tell . These machines pick up on changes in electric stream in the soundbox to monitor heartbeats . The wearable sensor does the same matter , though the flow is smaller , he said .
The oral contraceptive pill is designed to work for only about 3 minutes . That ’s just enough prison term for it to send a signal to the wearable detector that it should wake up and start forgather data point . That saves barrage tycoon , Savage said , and allows the wearable sensor to work for a week at a time .
From patient to doctor
The wearable sensor , which is an adhesive patch worn on the abdomen , can notice how active the patient is , like a Fitbit , aver Bob McQuade , the chief strategy officer at Otsuka Pharmaceutical . It can also determine if the person take the pill is lying down . [ 5 Ways Computers Boost Drug Discovery ]
Savage observe that the information sent from the wearable sensing element to the phone and from the phone app to the doctor ’s office isencrypted , and there is n’t a realistic way to whoop the signal from the pill to the wearable sensor without proceed in very tightlipped liaison with the patient .
McQuade noted that even though the data let doctors monitor if patients have taken their medicine , there ’s no grounds that the system improves adherence , intend that the patient role take the medicine as organize .
" Those experiment have n’t been done yet , " McQuade told Live Science . Even so , this variety of data might aid doctors utter to patients about medication usage and perhaps describe upright habit , he said .
Savage notice that adherence and right use is an ongoing job . For model , many people who omit a day ’s medicine — whatever it is for — will take two birth control pill the next day , even though people should n’t do that with some drug . " hoi polloi do thing that are logical at work , for instance — you miss a day , [ so ] you come in and do more employment — but not in pharmacology . "
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