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A woolgathering dieting lozenge that someday give up people to eat as much as they want without gaining weight seems possible , based on new enquiry into certain learning ability chemicals that influence how quickly we fire productive .
Scientists used science laboratory mice to turn down brain levels of endocannabinoids , chemicals produced by our body that are similar in molecular body structure to the active component in marijuana .
Stop exercising, eat as much as you want … and still lose weight? It sounds impossible, but researchers have made it happen in the lab.
premature enquiry has found that endocannabinoids act an important office inregulating energy metabolism . In the new study , stuff the activity of endocannabinoids in the brain enable mice to stay skinny without exercise or dieting . The researcher explain that the mice were in a " hypermetabolic country , " in which their soundbox were using up push ( that is , calories ) at a much higher rate than normal .
" We discovered that these mouse were resistant to obesity because theyburned fat caloriesmuch more expeditiously than normal mice do , " study researcher Daniele Piomelli , a professor at the University of California , Irvine , say in a statement . " We had known thatendocannabinoidsplay a critical role in cell vigour regularization , but this is the first sentence we determine a fair game where this occurs . "
This target is a chemical compound call 2 - AG , found in mellow levels in mammalian brains , and researchers think it plays a role in the brain circuits assure how the soundbox practice energy , which we get from food .
A late study by Piomelli found these compoundsmake us crave fat . To see if lowering the level of these compound had the opposite effect , Piomelli engineered the brain cells of shiner to express only low storey of this compound , then compared the beast ' demeanour and wellness with that of normal mice .
The limited mice ate more and moved less than their normal similitude , but quell tightfitting even on a gamy - fat diet . Not only did they look healthy , they had normal blood pressure , and no increased risk of heart disease and diabetes that usually come with a high-pitched - fat dieting .
The investigator determined that the modified mice’sbrown fatwas hyperactive — it was being turned into heat much faster than in the normal mice . Brown fatty tissue is a type of fat that maintain mammal warm , and this heat world fire off excess energy .
Jumping from research lab studies in shiner to factual health benefit for mankind is still a ways off , though , since it is difficult to make a drug that acts only in one brain area .
" To produce the trust effects , we would need to create a drug that blocks 2 - silver production in the head , something we ’re not yet able to do , " Piomelli said . " So do n’t cancel that gym rank just yet . "
The cogitation was bring out today ( March 6 ) in the journal Cell Metabolism .
